Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

Yuzhong Liu; Akiko Kochi; Amit S. Pithadia; Sanghyun Lee; Younwoo Nam; Michael W. Beck; Xiaoming He; Dongkuk Lee; Mi Hee Lim

doi:10.1021/ic400851w

Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

Yuzhong Liu
, Akiko Kochi
, Amit S. Pithadia
, Sanghyun Lee
, Younwoo Nam
, Michael W. Beck
, Xiaoming He
, Dongkuk Lee
, Mi Hee Lim

Eastern Illinois University

Producción científica › revisión exhaustiva

Idioma original	American English
Publicación	Inorganic Chemistry
Volumen	52
DOI	https://doi.org/10.1021/ic400851w
Estado	Published - jul 15 2013

Disciplines

Chemistry

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10.1021/ic400851wLicencia: Unspecified

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https://pubs.acs.org/doi/abs/10.1021/ic400851w

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title = "Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.",

author = "Yuzhong Liu and Akiko Kochi and Pithadia, \{Amit S.\} and Sanghyun Lee and Younwoo Nam and Beck, \{Michael W.\} and Xiaoming He and Dongkuk Lee and Lim, \{Mi Hee\}",

note = "A diphenylpropynone derivative, DPP2, has been recently demonstrated to target metal-associated amyloid-β (metal-Aβ) species implicated in Alzheimer's disease (AD). DPP2 was shown to interact with metal-Aβ species and subsequently control Aβ aggregation (reactivity) in vitro; however, its cytotoxicity has limited further biological applications.",

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day = "15",

doi = "10.1021/ic400851w",

language = "American English",

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journal = "Inorganic Chemistry",

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T1 - Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

AU - Liu, Yuzhong

AU - Kochi, Akiko

AU - Pithadia, Amit S.

AU - Lee, Sanghyun

AU - Nam, Younwoo

AU - Beck, Michael W.

AU - He, Xiaoming

AU - Lee, Dongkuk

AU - Lim, Mi Hee

N1 - A diphenylpropynone derivative, DPP2, has been recently demonstrated to target metal-associated amyloid-β (metal-Aβ) species implicated in Alzheimer's disease (AD). DPP2 was shown to interact with metal-Aβ species and subsequently control Aβ aggregation (reactivity) in vitro; however, its cytotoxicity has limited further biological applications.

PY - 2013/7/15

Y1 - 2013/7/15

UR - https://pubs.acs.org/doi/abs/10.1021/ic400851w

U2 - 10.1021/ic400851w

DO - 10.1021/ic400851w

M3 - Article

VL - 52

JO - Inorganic Chemistry

JF - Inorganic Chemistry

ER -