Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

Aseem Hussain; Minh Luong; Apryl Pooley; Britto P. Nathan

Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

Aseem Hussain, Minh Luong, Apryl Pooley, Britto P. Nathan

Eastern Illinois University

Eastern Illinois University

Producción científica › revisión exhaustiva

Resumen

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

Idioma original	American English
Publicación	Journal of Biomedical Science
Volumen	20
Estado	Published - 2013

Disciplines

Biology
Life Sciences
Neuroscience and Neurobiology

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title = "Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture",

abstract = " The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer{\textquoteright}s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).",

keywords = "ApoE, Neurite outgrowth, Neuronal differentiation, Olfaction, Olfactory neurons, Low-density lipoprotein receptor-related protein, Receptor-associated protein, Alzheimer{\textquoteright}s disease",

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year = "2013",

language = "American English",

volume = "20",

journal = "Journal of Biomedical Science",

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T1 - Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

AU - Hussain, Aseem

AU - Luong, Minh

AU - Pooley, Apryl

AU - Nathan, Britto P.

PY - 2013

Y1 - 2013

N2 - The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

AB - The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

KW - ApoE

KW - Neurite outgrowth

KW - Neuronal differentiation

KW - Olfaction

KW - Olfactory neurons

KW - Low-density lipoprotein receptor-related protein

KW - Receptor-associated protein

KW - Alzheimer’s disease

M3 - Article

VL - 20

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

ER -