Direct selection of hepatoma cell variants deficient in α1-antitrypsin gene expression

Gary A. Bulla; R. E. K. Fournier

doi:10.1007/BF01235759

Direct selection of hepatoma cell variants deficient in α1-antitrypsin gene expression

Fred Hutchinson Cancer Research Center

Producción científica › revisión exhaustiva

Idioma original	American English
Publicación	Somatic Cell and Molecular Genetics
Volumen	18
DOI	https://doi.org/10.1007/BF01235759
Estado	Published - jul 1 1992
Publicado de forma externa	Sí

Disciplines

Genetics
Biology
Molecular Biology

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10.1007/BF01235759Licencia: Unspecified

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https://link.springer.com/article/10.1007/BF01235759

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title = "Direct selection of hepatoma cell variants deficient in α1-antitrypsin gene expression",

author = "Bulla, \{Gary A.\} and Fournier, \{R. E. K.\}",

note = "Expression plasmids containing the human α 1-antitrypsin (α 1 AT) promoter fused to either adenine phosphoribosyltransferase (aprt) or xanthine-guanine phosphoribosyltransferase (gpt) coding sequences were sequentially introduced into APRT − HPRT − rat hepatoma cells. Stable transfectants expressing both transgenes were isolated and characterized. Nonexpressing variants were subsequently obtained by selecting against expression of one or both transgenes.",

year = "1992",

month = jul,

day = "1",

doi = "10.1007/BF01235759",

language = "American English",

volume = "18",

journal = "Somatic Cell and Molecular Genetics",

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TY - JOUR

T1 - Direct selection of hepatoma cell variants deficient in α1-antitrypsin gene expression

AU - Bulla, Gary A.

AU - Fournier, R. E. K.

N1 - Expression plasmids containing the human α 1-antitrypsin (α 1 AT) promoter fused to either adenine phosphoribosyltransferase (aprt) or xanthine-guanine phosphoribosyltransferase (gpt) coding sequences were sequentially introduced into APRT − HPRT − rat hepatoma cells. Stable transfectants expressing both transgenes were isolated and characterized. Nonexpressing variants were subsequently obtained by selecting against expression of one or both transgenes.

PY - 1992/7/1

Y1 - 1992/7/1

UR - https://link.springer.com/article/10.1007/BF01235759

U2 - 10.1007/BF01235759

DO - 10.1007/BF01235759

M3 - Article

VL - 18

JO - Somatic Cell and Molecular Genetics

JF - Somatic Cell and Molecular Genetics

ER -