Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

Yuzhong Liu; Akiko Kochi; Amit S. Pithadia; Sanghyun Lee; Younwoo Nam; Michael W. Beck; Xiaoming He; Dongkuk Lee; Mi Hee Lim

doi:10.1021/ic400851w

Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

Yuzhong Liu, Akiko Kochi, Amit S. Pithadia, Sanghyun Lee, Younwoo Nam, Michael W. Beck, Xiaoming He, Dongkuk Lee, Mi Hee Lim

Eastern Illinois University

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Inorganic Chemistry
Volume	52
DOIs	https://doi.org/10.1021/ic400851w
State	Published - Jul 15 2013

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Chemistry

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@article{def84def723b4b6da9ee5d841118c5dc,

title = "Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.",

author = "Yuzhong Liu and Akiko Kochi and Pithadia, {Amit S.} and Sanghyun Lee and Younwoo Nam and Beck, {Michael W.} and Xiaoming He and Dongkuk Lee and Lim, {Mi Hee}",

note = "A diphenylpropynone derivative, DPP2, has been recently demonstrated to target metal-associated amyloid-β (metal-Aβ) species implicated in Alzheimer's disease (AD). DPP2 was shown to interact with metal-Aβ species and subsequently control Aβ aggregation (reactivity) in vitro; however, its cytotoxicity has limited further biological applications.",

year = "2013",

month = jul,

day = "15",

doi = "10.1021/ic400851w",

language = "American English",

volume = "52",

journal = "Inorganic Chemistry",

}

TY - JOUR

T1 - Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

AU - Liu, Yuzhong

AU - Kochi, Akiko

AU - Pithadia, Amit S.

AU - Lee, Sanghyun

AU - Nam, Younwoo

AU - Beck, Michael W.

AU - He, Xiaoming

AU - Lee, Dongkuk

AU - Lim, Mi Hee

N1 - A diphenylpropynone derivative, DPP2, has been recently demonstrated to target metal-associated amyloid-β (metal-Aβ) species implicated in Alzheimer's disease (AD). DPP2 was shown to interact with metal-Aβ species and subsequently control Aβ aggregation (reactivity) in vitro; however, its cytotoxicity has limited further biological applications.

PY - 2013/7/15

Y1 - 2013/7/15

UR - https://pubs.acs.org/doi/abs/10.1021/ic400851w

U2 - 10.1021/ic400851w

DO - 10.1021/ic400851w

M3 - Article

VL - 52

JO - Inorganic Chemistry

JF - Inorganic Chemistry

ER -

Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

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