Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

Aseem Hussain, Minh Luong, Apryl Pooley, Britto P. Nathan

Research output: Contribution to journal › Article › peer-review

Abstract

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).
Original languageAmerican English
JournalJournal of Biomedical Science
Volume20
StatePublished - 2013

Keywords

  • ApoE
  • Neurite outgrowth
  • Neuronal differentiation
  • Olfaction
  • Olfactory neurons
  • Low-density lipoprotein receptor-related protein
  • Receptor-associated protein
  • Alzheimer’s disease

Disciplines

  • Biology
  • Life Sciences
  • Neuroscience and Neurobiology

Access to Document

  • fulltext.pdfFinal published version, 1.93 MBLicense: Unspecified

    Cite this