Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

Bp Nathan; S Bellosta; Da Sanan; Kh Weisgraber; Rw Mahley; Re Pitas; Britto P. Nathan

doi:10.1126/science.8171342

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

Bp Nathan
, S Bellosta
, Da Sanan
, Kh Weisgraber
, Rw Mahley
, Re Pitas
, Britto P. Nathan

Eastern Illinois University

University of California, San Francisco
IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Science
Volume	264
DOIs	https://doi.org/10.1126/science.8171342
State	Published - May 6 1994

Disciplines

Endocrinology
Biology
Internal Medicine

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@article{7e32b1225ec84cd1b91076025299155d,

title = "Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro",

author = "Bp Nathan and S Bellosta and Da Sanan and Kh Weisgraber and Rw Mahley and Re Pitas and Nathan, \{Britto P.\}",

note = "Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease. The effects of apoE on neuronal growth were determined in cultures of dorsal root ganglion neurons. In the presence of beta-migrating very low density lipoproteins (beta-VLDL), apoE3 increased neurite outgrowth, whereas apoE4 decreased outgrowth.",

year = "1994",

month = may,

day = "6",

doi = "10.1126/science.8171342",

language = "American English",

volume = "264",

journal = "Science",

}

TY - JOUR

T1 - Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

AU - Nathan, Bp

AU - Bellosta, S

AU - Sanan, Da

AU - Weisgraber, Kh

AU - Mahley, Rw

AU - Pitas, Re

AU - Nathan, Britto P.

N1 - Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease. The effects of apoE on neuronal growth were determined in cultures of dorsal root ganglion neurons. In the presence of beta-migrating very low density lipoproteins (beta-VLDL), apoE3 increased neurite outgrowth, whereas apoE4 decreased outgrowth.

PY - 1994/5/6

Y1 - 1994/5/6

UR - http://science.sciencemag.org/content/sci/264/5160/850.full.pdf

U2 - 10.1126/science.8171342

DO - 10.1126/science.8171342

M3 - Article

VL - 264

JO - Science

JF - Science

ER -

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

Disciplines

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